Recruitment and activation of Raf-1 kinase by nitric oxide-activated Ras.

@article{Deora2000RecruitmentAA,
  title={Recruitment and activation of Raf-1 kinase by nitric oxide-activated Ras.},
  author={Ami A Deora and David P. Hajjar and Harry M. Lander},
  journal={Biochemistry},
  year={2000},
  volume={39 32},
  pages={9901-8}
}
Nitric oxide (NO) and related species serve as cellular messengers in various physiological and pathological processes. The monomeric G protein, Ras, transduces multiple signaling pathways with varying biological responses. We have previously reported that NO triggers Ras activation and recruitment of an effector, phosphatidylinositol 3'-kinase (PI3K) and Ras-dependent activation of mitogen-activated protein (MAP) kinases which include extracellular signal regulated kinases (ERKs), c-Jun NH(2… CONTINUE READING

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