Recruiting polycomb to chromatin.

  title={Recruiting polycomb to chromatin.},
  author={Ila van Kruijsbergen and Saartje Hontelez and Gert Jan C. Veenstra},
  journal={The international journal of biochemistry & cell biology},
Polycomb group (PcG) proteins are key regulators in establishing a transcriptional repressive state. Polycomb Repressive Complex 2 (PRC2), one of the two major PcG protein complexes, is essential for proper differentiation and maintenance of cellular identity. Multiple factors are involved in recruiting PRC2 to its genomic targets. In this review, we will discuss the role of DNA sequence, transcription factors, pre-existing histone modifications, and RNA in guiding PRC2 towards specific genomic… CONTINUE READING
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