Recruiting patients to medical research: double blind randomised trial of "opt-in" versus "opt-out" strategies.


OBJECTIVE To evaluate the effect of opt-in compared with opt-out recruitment strategies on response rate and selection bias. DESIGN Double blind randomised controlled trial. SETTING Two general practices in England. PARTICIPANTS 510 patients with angina. INTERVENTION Patients were randomly allocated to an opt-in (asked to actively signal willingness… (More)


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