Recruiting Zn2+ to mediate potent, specific inhibition of serine proteases.

@article{Katz1999RecruitingZT,
  title={Recruiting Zn2+ to mediate potent, specific inhibition of serine proteases.},
  author={Bradley A. Katz and Christine Luong},
  journal={Journal of molecular biology},
  year={1999},
  volume={292 3},
  pages={669-84}
}
As regulators of ubiquitous biological processes, serine proteases can cause disease states when inappropriately expressed or regulated, and are thus rational targets for inhibition by drugs. Recently we described a new inhibition mechanism applicable for the development of potent, selective small molecule serine protease inhibitors that recruit physiological Zn2+ to mediate high affinity (sub-nanomolar) binding. To demonstrate some of the structural principles by which the selectivity of Zn2… CONTINUE READING