Recql5 plays an important role in DNA replication and cell survival after camptothecin treatment.

@article{Hu2009Recql5PA,
  title={Recql5 plays an important role in DNA replication and cell survival after camptothecin treatment.},
  author={Yiduo Hu and Xincheng Lu and Guangjin Zhou and Ellen Barnes and Guangbin Luo},
  journal={Molecular biology of the cell},
  year={2009},
  volume={20 1},
  pages={
          114-23
        }
}
Disruption of replication can lead to loss of genome integrity and increase of cancer susceptibility in mammals. Thus, a replication impediment constitutes a formidable challenge to these organisms. Recent studies indicate that homologous recombination (HR) plays an important role in suppressing genome instability and promoting cell survival after exposure to various replication inhibitors, including a topoisomerase I inhibitor, camptothecin (CPT). Here, we report that the deletion of RecQ… CONTINUE READING

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