Recovery of the hypothalamic-pituitary-adrenal response to stress. Effect of stress intensity, stress duration and previous stress exposure.

@article{Garca2000RecoveryOT,
  title={Recovery of the hypothalamic-pituitary-adrenal response to stress. Effect of stress intensity, stress duration and previous stress exposure.},
  author={Agustina Garc{\'i}a and Octavi Mart{\'i} and Astrid Vall{\`e}s and Silvina Dal-Zotto and Antonio Armario},
  journal={Neuroendocrinology},
  year={2000},
  volume={72 2},
  pages={114-25}
}
Pathological consequences of stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis may be related to the duration rather than to the intensity of HPA axis activation after exposure to the stressor. Consequently a fine analysis of post-stress events is of importance. The present experiments were designed to study the importance of three key factors in HPA recovery: intensity of the stressor (experiment 1), duration of exposure to the stressor (experiment 2) and previous… CONTINUE READING