Recovery of prostacyclin capacity of irradiated endothelial cells and the protective effect of vitamin C.

@article{Eldor1987RecoveryOP,
  title={Recovery of prostacyclin capacity of irradiated endothelial cells and the protective effect of vitamin C.},
  author={Amiram Eldor and Israel Vlodavsky and Emanuel Riklis and Zvi Fuks},
  journal={Prostaglandins},
  year={1987},
  volume={34 2},
  pages={
          241-55
        }
}
16 Citations
Prostacyclin production in cultured endothelial cells is highly sensitive to low doses of ionizing radiation.
TLDR
It is suggested that low dose irradiation inhibits the prostacyclin production by changing the cellular membranes transiently.
Interleukin-32 positively regulates radiation-induced vascular inflammation.
Radiation-induced afferent arteriolar endothelial-dependent dysfunction involves decreased epoxygenase metabolites.
TLDR
Results indicate that afferent arteriolar endothelial dysfunction involves a decrease in EPOX metabolites that precedes the development of proteinuria, azotemia, and hypertension in irradiated rats.
Arachidonic metabolism and radiation toxicity in cultures of vascular endothelial cells.
REGULATION OF ANTI-THROMBOGENETIC FACTORS IN ENDOTHELIUM
TLDR
The production of prostacyclin from endothelial cells is under adrenergic control, modulating the effect of ß-adrenoceptor blockers, and Signal transduction through adenylate cyclase, protein kinase C and tyrosine kinase pathways is critical in the regulation of t-PA and PAI-1 production from endothelium.
Selected Endothelial Responses after Ionizing Radiation Exposure
TLDR
Experimental studies are warranted to fulfill the urgent need to identify noninvasive biomarkers for an early detection and potential interventions—together with a healthy lifestyle—that may prevent or mitigate these adverse effects.
Amelioration of radiation nephropathy by acetylsalicylic acid.
TLDR
Analysis of the kidneys at 12 months after irradiation demonstrated a substantially lower level of damage in the ASA-treated mice compared with daltroban-treated and radiation-only animals, indicating that long-term treatment with ASA is effective in reducing renal functional impairment after irradiated animals.
Selected Endothelial Responses after Ionizing Radiation Exposure Selected Endothelial Responses after Ionizing Radiation Exposure
TLDR
Experimental studies are warranted to fulfill the urgent need to identify noninvasive biomarkers for an early detection and potential inter- ventions that may prevent or mitigate these adverse effects of radiation treatment-related comorbidity.
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