Recovery of prostacyclin capacity of irradiated endothelial cells and the protective effect of vitamin C.

@article{Eldor1987RecoveryOP,
  title={Recovery of prostacyclin capacity of irradiated endothelial cells and the protective effect of vitamin C.},
  author={Amiram Eldor and Israel Vlodavsky and Emanuel Riklis and Zvi Fuks},
  journal={Prostaglandins},
  year={1987},
  volume={34 2},
  pages={
          241-55
        }
}
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16 Citations

16 Citations

Radiation reduces cyclooxygenase activity in cultured human endothelial cells at low doses.
Prostacyclin production in cultured endothelial cells is highly sensitive to low doses of ionizing radiation.
TLDR
It is suggested that low dose irradiation inhibits the prostacyclin production by changing the cellular membranes transiently.
Endothelial prostacyclin production, synergistic effect between adrenergic stimulating and blocking drugs.
Interleukin-32 positively regulates radiation-induced vascular inflammation.
Radiation-induced afferent arteriolar endothelial-dependent dysfunction involves decreased epoxygenase metabolites.
TLDR
Results indicate that afferent arteriolar endothelial dysfunction involves a decrease in EPOX metabolites that precedes the development of proteinuria, azotemia, and hypertension in irradiated rats.
Arachidonic metabolism and radiation toxicity in cultures of vascular endothelial cells.
REGULATION OF ANTI-THROMBOGENETIC FACTORS IN ENDOTHELIUM
TLDR
The production of prostacyclin from endothelial cells is under adrenergic control, modulating the effect of ß-adrenoceptor blockers, and Signal transduction through adenylate cyclase, protein kinase C and tyrosine kinase pathways is critical in the regulation of t-PA and PAI-1 production from endothelium.
Selected Endothelial Responses after Ionizing Radiation Exposure
TLDR
Experimental studies are warranted to fulfill the urgent need to identify noninvasive biomarkers for an early detection and potential interventions—together with a healthy lifestyle—that may prevent or mitigate these adverse effects.
Amelioration of radiation nephropathy by acetylsalicylic acid.
TLDR
Analysis of the kidneys at 12 months after irradiation demonstrated a substantially lower level of damage in the ASA-treated mice compared with daltroban-treated and radiation-only animals, indicating that long-term treatment with ASA is effective in reducing renal functional impairment after irradiated animals.
Selected Endothelial Responses after Ionizing Radiation Exposure Selected Endothelial Responses after Ionizing Radiation Exposure
TLDR
Experimental studies are warranted to fulfill the urgent need to identify noninvasive biomarkers for an early detection and potential inter- ventions that may prevent or mitigate these adverse effects of radiation treatment-related comorbidity.
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References

SHOWING 1-10 OF 28 REFERENCES
The effect of radiation on prostacycliln (PG2) productnio by cultured endothelial cells
IRRADIATION DECREASES VASCULAR PROSTACYCLIN FORMATION WITH NO CONCOMITANT EFFECT ON PLATELET THROMBOXANE PRODUCTION
The influence of gamma radiation on arachidonic acid release and prostacyclin synthesis.
Prostacyclin synthesis in irradiated endothelial cells cultured from bovine aorta.
TLDR
There was an increased platelet interaction with irradiated monolayers, as a result of platelet adherence to subendothelial matrix exposed after cell detachment, however, irradiation did not alter the nonadherent property of the endothelial cell surface toward platelets.
Cultured endothelial cells increase their capacity to synthesize prostacyclin following the formation of a contact inhibited cell monolayer
TLDR
Increased capacity of the cells to synthesize PGI2 and PGE2 was observed as a function of time in culture, regardless of the type of stimulation, and is likely to reflect an increased activity of the PG synthetase system associated with the formation of a contact inhibited endothelial cell monolayer.
Radiation-induced changes in production of prostaglandins F2 alpha, E, and thromboxane B2 in guinea pig parenchymal lung tissues.
  • L. SteelG. Catravas
  • Medicine, Biology
    International journal of radiation biology and related studies in physics, chemistry, and medicine
  • 1982
TLDR
The data suggest that significant alterations in prostaglandin and thromboxane concentrations in parenchymal lung tissues occur following irradiation, in a dose-dependent manner, and that altered responsiveness to H-1 receptor stimulation and divalent cation transport also occur.
Radiation Effects on Eicosanoid Formation
TLDR
It will become apparent that anUnderstanding of the relationship of eicosanoid metabolism to irradiation may be important toward the understanding of the role of radiation in malignancy.
Radical scavenging as the mechanism for stimulation of prostaglandin cyclooxygenase and depression of inflammation by lipoic acid and sodium iodide.
Radiation induced alterations in rabbit aortic prostacyclin formation.
Mechanism for irreversible self-deactivation of prostaglandin synthetase.
TLDR
A mechanism has been devised which accounts for the self-deactivation phenomenon, the effect of phenol and methional, the disulfide at the active site, and the pathway of substrate oxygenation.
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