Recovery of macular pigment spectrum in vivo using hyperspectral image analysis.

@article{Fawzi2011RecoveryOM,
  title={Recovery of macular pigment spectrum in vivo using hyperspectral image analysis.},
  author={Amani A Fawzi and Noah Lee and Jennifer H Acton and Andrew F. Laine and R Theodore Smith},
  journal={Journal of biomedical optics},
  year={2011},
  volume={16 10},
  pages={
          106008
        }
}
We investigated the feasibility of a novel method for hyperspectral mapping of macular pigment (MP) in vivo. Six healthy subjects were recruited for noninvasive imaging using a snapshot hyperspectral system. The three-dimensional full spatial-spectral data cube was analyzed using non-negative matrix factorization (NMF), wherein the data was decomposed to give spectral signatures and spatial distribution, in search for the MP absorbance spectrum. The NMF was initialized with the in vitro MP… CONTINUE READING

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