Recovery of hippocampal network connectivity correlates with cognitive improvement in mild Alzheimer's disease patients treated with donepezil assessed by resting-state fMRI.

@article{Goveas2011RecoveryOH,
  title={Recovery of hippocampal network connectivity correlates with cognitive improvement in mild Alzheimer's disease patients treated with donepezil assessed by resting-state fMRI.},
  author={Joseph S. Goveas and Chunming Xie and B. Douglas Ward and Zhilin Wu and Wenjun Li and Malgorzata Franczak and Jennifer L. Jones and Piero Antuono and Shi-Jiang Li},
  journal={Journal of magnetic resonance imaging : JMRI},
  year={2011},
  volume={34 4},
  pages={
          764-73
        }
}
PURPOSE To identify the neural correlates of cognitive improvement in mild Alzheimer's disease (AD) subjects following 12 weeks of donepezil treatment. MATERIALS AND METHODS Resting-state functional connectivity magnetic resonance imaging (R-fMRI) was used to measure the hippocampal functional connectivity (HFC) in 14 mild AD and 18 age-matched normal (CN) subjects. AD subjects were scanned at baseline and after donepezil treatment. CN subjects were scanned only at baseline as a reference to… CONTINUE READING
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