Recovery of dopamine transporters with methamphetamine detoxification is not linked to changes in dopamine release

@article{Volkow2015RecoveryOD,
  title={Recovery of dopamine transporters with methamphetamine detoxification is not linked to changes in dopamine release},
  author={Nora D. Volkow and Gene-Jack Wang and Lisa Smith and Joanna S. Fowler and Frank Telang and Jean Logan and Dardo Tomasi},
  journal={NeuroImage},
  year={2015},
  volume={121},
  pages={20-28}
}
Methamphetamine's widepread abuse and concerns that it might increase Parkinson's disease led us to assess if the reported loss of dopamine transporters (DAT) in methamphetamine abusers (MA) reflected damage to dopamine neurons. Using PET with [(11)C]cocaine to measure DAT, and with [(11)C]raclopride to measure dopamine release (assessed as changes in specific binding of [(11)C]raclopride between placebo and methylphenidate), which was used as a marker of dopamine neuronal function, we show… CONTINUE READING

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