Recovery of central noradrenergic neurons one year after the administration of the neurotoxin DSP4.

@article{Wolfman1994RecoveryOC,
  title={Recovery of central noradrenergic neurons one year after the administration of the neurotoxin DSP4.},
  author={Claudia Wolfman and V Ab{\'o} and Daniel Horacio Calvo and Jared Medina and Federico Dajas and Rodolfo Silveira},
  journal={Neurochemistry international},
  year={1994},
  volume={25 4},
  pages={395-400}
}
The long-term effects of the systemic administration of DSP4 (N-(2-chloroethyl)N-ethyl-2-bromobenzylamine hydrochloride), a selective noradrenergic neurotoxin, on the endogenous levels of monoamines and their metabolites and on alpha- and beta-adrenoceptors in selected brain regions of the rat were examined. After 7 days, DSP4 caused a marked reduction (about 80%) of endogenous noradrenaline levels in locus coeruleus-innervated regions. At 90, 240 and 300 days after DSP4 injection, a partial… CONTINUE READING

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