Recovery of antediluvian DNA

  title={Recovery of antediluvian DNA},
  author={Tomas Lindahl},
  • T. Lindahl
  • Published 21 October 1993
  • Biology, Medicine
  • Nature

The alien presence: Palaeoentomological approaches to trade and migration

  • G. King
  • Environmental Science, Geography
  • 2010
This thesis addresses the potential of palaeoentomological remains to stand as evidence of past trade and culture contact by superimposing the physiological and ecological habits of modern species over the archaeological record and found that stenotopic insects may reliably be employed as indicators of their associated habitats.

Fragmentation of Contaminant and Endogenous DNA in Ancient Samples Determined by Shotgun Sequencing; Prospects for Human Palaeogenomics

It is observed that bleach treatment appears to create a depurination-associated fragmentation pattern in resulting contaminant sequences that is indistinguishable from previously described endogenous sequences, and the nucleotide composition pattern observed in 5′ and 3′ ends of contaminants is much more complex than the flat pattern previously described in some Neandertal contaminants.

Postmortem Miscoding Lesions in Sequence Analysis of Human Ancient Mitochondrial DNA

This study identifies the previously unreported presence of oxidative DNA damage and proposes that damage to degraded DNA templates is highly specific in type, correlating with the geographic location and the taphonomic conditions of the depositional environment from which the remains are recovered.

Advances in ancient DNA studies

A series of large scale studies have begun to reveal the true potential of aDNA to record the methods and processes of evolution, providing a unique way to test models and assumptions commonly used to reconstruct patterns of Evolution, population genetics and palaeoecological change.

Molecular archeology of human viruses.

Accurate depiction of uncertainty in ancient DNA research: The case of Neandertal ancestry in Africa

Some guidelines on how to recognize accurate depiction of uncertainty are provided and examples of how effective engagement with content experts in archaeology and biological anthropology can lead to stronger and more easily communicated scientific outcomes are provided.

Uncertainties in synthetic DNA-based data storage

The general procedures of the state-of-the-art DNA-based digital data storage methods are summarized, highlighting the uncertainties involved in each step as well as potential approaches to correct them.

DNA from resin-embedded organisms: Past, present and future

It is demonstrated here, for the first time, that although a labile molecule, DNA is still present in platypodine beetles embedded in six- year-old and two-year-old resin pieces from Hymenaea verrucosa collected in Madagascar, concluding that it is therefore possible to study genomics from resin-embedded organisms, although the time limits remain to be determined.

Diagnostiquer un état de santé bucco-dentaire par une double approche macroscopique et métagénomique : application à une population rurale française du XVIIIe siècle

Le recent developpement des technologies de sequencage de l'ADN ancien (ADNa) a haut debit (High-Throughput DNA sequencing : HTS) a permis l'acces et la caracterisation des communautes microbiennes



DNA sequences from a fossil termite in Oligo-Miocene amber and their phylogenetic implications.

Phylogenetic analysis of fossil and extant 18S rDNA confirmed morphological cladistic analyses of living dictyopterans (termites, cockroaches, and mantids) and affects molecular phylogenetic hypotheses of termites in this, the oldest DNA yet characterized.

Bacterial DNA in Clarkia fossils.

Analysis of extracts prepared from the plant remains shows that the high molecular mass (HMM) DNA that can be detected in some extracts from Clarkia fossils is mostly, if not exclusively, of bacterial origin.

Structural biopolymer preservation in Miocene leaf fossils from the Clarkia site, northern Idaho.

  • G. LoganJ. BoonG. Eglinton
  • Environmental Science
    Proceedings of the National Academy of Sciences of the United States of America
  • 1993
The 17- to 20-million-year-old locality at Clarkia, northern Idaho, is renowned for yielding amplifiable DNA from a magnolia leaf fossil, but molecular preservation of biomacromolecules is highly selective; structural polysaccharides, cutin polyesters, and proteins were not preserved in detectable quantity in the leaf tissues.

Chloroplast DNA sequence from a Miocene Magnolia species

The extraction of DNA from fossil leaf samples from the Miocene Clarkia deposit, the amplification of an 820-base pair DNA fragment from the chloroplast gene rbcL from a fossil of the genus Magnolia, and its subsequent sequencing extend the ability to analyse ancient DNA and may open new avenues into problems in palaeobotany, biogeography, and in the calibration of mutation rates.

Amplification and sequencing of DNA from a 120–135-million-year-old weevil

The results revealed that the PCR-amplifted material is that of the extinct nemonychid weevil, which represents the oldest fossil DNA ever extracted and sequenced, extending by 80 million years the age of any previously reported DNA.

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

  • C. RichterJ. ParkB. Ames
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1988
The oxidized base, 8-hydroxydeoxyguanosine (oh8dG), 1 of approximately 20 known radiation damage products, has been assayed in the DNA of rat liver and may be responsible for the observed high mutation rate of mtDNA.

Instability and decay of the primary structure of DNA

The spontaneous decay of DNA is likely to be a major factor in mutagenesis, carcinogenesis and ageing, and also sets limits for the recovery of DNA fragments from fossils.