Recovery of a recombinant salmonid alphavirus fully attenuated and protective for rainbow trout.

@article{Moriette2006RecoveryOA,
  title={Recovery of a recombinant salmonid alphavirus fully attenuated and protective for rainbow trout.},
  author={Coralie Moriette and Monique Leberre and Annie Lamoureux and Thanh-Lan Lai and Michel Br{\'e}mont},
  journal={Journal of virology},
  year={2006},
  volume={80 8},
  pages={4088-98}
}
Sleeping disease virus (SDV) is a member of the new Salmonid alphavirus genus within the Togaviridae family. The single-stranded RNA genome of SDV is 11,894 nucleotides long, excluding the 3' poly(A) tail. A full-length cDNA has been generated; the cDNA was fused to a hammerhead ribozyme sequence at the 5' end and inserted into a transcription plasmid (pcDNA3) backbone, yielding pSDV. By transfection of pSDV into fish cells, recombinant SDV (rSDV) was successfully recovered. Demonstration of… CONTINUE READING
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