Recovery of Aging-Related Size Increase of Skin Epithelial Cells: In vivo Mouse and In vitro Human Study

@inproceedings{Sokolov2015RecoveryOA,
  title={Recovery of Aging-Related Size Increase of Skin Epithelial Cells: In vivo Mouse and In vitro Human Study},
  author={Igor Sokolov and Natali V. Guz and Swaminathan Smita Iyer and A. J. Hewitt and Nina A. Sokolov and Joseph S. Erlichman and Craig D Woodworth},
  booktitle={PloS one},
  year={2015}
}
The size increase of skin epithelial cells during aging is well-known. Here we demonstrate that treatment of aging cells with cytochalasin B substantially decreases cell size. This decrease was demonstrated on a mouse model and on human skin cells in vitro. Six nude mice were treated by topical application of cytochalasin B on skin of the dorsal left midsection for 140 days (the right side served as control for placebo treatment). An average decrease in cell size of 56±16% resulted. A reduction… CONTINUE READING

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