Recovery from severe hematopoietic suppression using recombinant human granulocyte-macrophage colony-stimulating factor.

@article{Monroy1988RecoveryFS,
  title={Recovery from severe hematopoietic suppression using recombinant human granulocyte-macrophage colony-stimulating factor.},
  author={Rodney L Monroy and Robert Skelly and Peter R. Taylor and Alain Dubois and Robert E Donahue and Thomas J Macvittie},
  journal={Experimental hematology},
  year={1988},
  volume={16 5},
  pages={344-8}
}
The ability of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) to enhance recovery of a radiation-suppressed hematopoietic system was evaluated in a nonuniform radiation exposure model using the rhesus monkey. Recombinant human GM-CSF treatment for 7 days after a lethal, nonuniform radiation exposure of 800 cGy was sufficient to enhance hematopoietic reconstitution, leading to an earlier recovery. Monkeys were treated with 72,000 U/kg/day of rhGM-CSF delivered… CONTINUE READING
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