Recovery from mu-opioid receptor desensitization after chronic treatment with morphine and methadone.

@article{Quillinan2011RecoveryFM,
  title={Recovery from mu-opioid receptor desensitization after chronic treatment with morphine and methadone.},
  author={Nidia Quillinan and Elaine K Lau and Michael S Virk and Mark von Zastrow and John Michael Williams},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 12},
  pages={4434-43}
}
Chronic treatment with morphine results in a decrease in μ-opioid receptor sensitivity, an increase in acute desensitization, and a reduction in the recovery from acute desensitization in locus ceruleus neurons. With acute administration, morphine is unlike many other opioid agonists in that it does not mediate robust acute desensitization or induce receptor trafficking. This study compares μ-opioid receptor desensitization and trafficking in brain slices taken from rats treated for 6-7 d with… CONTINUE READING