Recovery from ketamine-induced amnesia by blockade of GABA-A receptor in the medial prefrontal cortex of mice

@article{Farahmandfar2017RecoveryFK,
  title={Recovery from ketamine-induced amnesia by blockade of GABA-A receptor in the medial prefrontal cortex of mice},
  author={M. Farahmandfar and Ardeshir Akbarabadi and Atefeh Bakhtazad and M. Zarrindast},
  journal={Neuroscience},
  year={2017},
  volume={344},
  pages={48-55}
}
Ketamine and other noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonists are known to induce deficits in learning and cognitive performance sensitive to prefrontal cortex (PFC) functions. The interaction of a glutamatergic and GABAergic systems is essential for many cognitive behaviors. In order to understand the effect of γ-aminobutyric acid (GABA)/glutamate interactions on learning and memory, we investigated the effects of intra medial prefrontal cortex (mPFC) injections of… Expand
Role of CA1 GABAA and GABAB receptors on learning deficit induced by D-AP5 in passive avoidance step-through task
TLDR
The results suggest that the microinjection of GABAA and GABAB agents into the CA1 region differently affects memory acquisition deficit induced by D-AP5, and the activation or blockade of GABABRs induced a similar and dual effect. Expand
Cortical and raphe GABAA, AMPA receptors and glial GLT-1 glutamate transporter contribute to the sustained antidepressant activity of ketamine
TLDR
The results suggest the need to test for the concomitant prescription of ketamine and BZD to see whether its sustained antidepressant activity is maintained in TRD patients, and highlight the role of neuronal-glial adaptation in these effects. Expand
Cortical and raphe GABAA, AMPA receptors and glial GLT-1 glutamate transporter contribute to the sustained antidepressant activity of ketamine
TLDR
The results suggest the need to test for the concomitant prescription of ketamine and BZD to see whether its sustained antidepressant activity is maintained in TRD patients, and highlight the role of neuronal-glial adaptation in these effects. Expand
Blockage of NMDA- and GABA(A) Receptors Improves Working Memory Selectivity of Primate Prefrontal Neurons
The ongoing activity of prefrontal neurons after a stimulus has disappeared is considered a neuronal correlate of working memory. It depends on the delicate but poorly understood interplay betweenExpand
Fast-acting antidepressant activity of ketamine: highlights on brain serotonin, glutamate, and GABA neurotransmission in preclinical studies.
TLDR
Evidence for mPFC neurotransmission abnormalities in major depressive disorder (MDD) and their potential impact on neural circuits (mPFC/DRN) are reviewed, with results from recent preclinical studies showing that ketamine, at antidepressant-relevant doses, induces neuronal adaptations that involve the glutamate-excitatory/GABA-inhibitory balance. Expand
Hippocampal GABAA antagonism reverses the novel object recognition deficit in sub-chronic phencyclidine-treated rats
TLDR
Findings indicate that the scPCP‐induced NOR deficit can be rescued by reducing GABAA receptor stimulation in vHPC, and also indicates that excessive GAB AA receptor signalling in the vH PC has a deleterious effect on NOR in normal rats. Expand
Ketamine abuse potential and use disorder
TLDR
It is hypothesized that ketamine blocks NMDA receptors on gamma-aminobutyric acid neurons inside the thalamic reticular nucleus, which leads to disinhibition of dopaminergic neurons and increased release of dopamine. Expand
Ketamine-induced hypnosis and neuroplasticity in mice is associated with disrupted p-MEK/p-ERK sequential activation and sustained upregulation of survival p-FADD in brain cortex: Involvement of GABAA receptor
TLDR
It is suggested that hypnotic and subhypnotic doses of KET inducing uncoupling of p‐MEK to p‐ERK signal and regulation of p-ERK (downregulation) and p‐FADD (upregulation) may participate in the expression of some of its adverse effects (e.g. amnesia, dissociative effects). Expand
GluN2A-selective positive allosteric modulator-nalmefene-flumazenil reverses ketamine-fentanyl-dexmedetomidine-induced anesthesia and analgesia in rats
TLDR
The potential application of the PNF combination with PAM combined with nalmefene and flumazenil in reversing the actions of an anesthetic combination is suggested. Expand
PKA-CREB-BDNF signaling pathway mediates propofol-induced long-term learning and memory impairment in hippocampus of rats
TLDR
The results indicated that neonatal propofol exposure can significantly result in long-term learning and memory impairment in adulthood, related to down-regulation of PKA-CREB-BDNF signaling pathway. Expand
...
1
2
...

References

SHOWING 1-10 OF 64 REFERENCES
Post-training systemic and intra-amygdala administration of the GABA-B agonist baclofen impairs retention.
TLDR
The results support the view that the GABAergic system is involved in the modulation of memory storage and that the amygdaloid complex may be a critical site for effects of drugs affecting the inhibitory avoidance response. Expand
Inhibition of morphine-induced amnesia in morphine-sensitized mice: Involvement of dorsal hippocampal GABAergic receptors
TLDR
It is suggested that morphine sensitization reverses the impairment of memory induced by morphine and that GABAergic receptors of the dorsal hippocampus may play an important role in this effect. Expand
GABAB/NMDA receptor interaction in the regulation of extracellular dopamine levels in rodent prefrontal cortex and striatum
TLDR
The findings support a model in which NMDA/glycine-site agonists modulate DA release in part through presynaptic GABA(B) receptors on DA terminals, with both GABA( B) ligands and GLY significantly modulating AMPH-induced DA release. Expand
Ketamine impairs recognition memory consolidation and prevents learning-induced increase in hippocampal brain-derived neurotrophic factor levels
TLDR
It is shown for the first time that ketamine disrupts the consolidation phase of long-term recognition memory and the findings suggest that the amnestic effects of ketamine might be at least partially mediated by an influence on BDNF signaling in the hippocampus. Expand
Ketamine affects memory consolidation: Differential effects in T-maze and passive avoidance paradigms in mice
TLDR
The data suggest that repeated anesthetic doses of ketamine block NMDA receptors and affect memory consolidation, and NMDA mechanisms antagonized by ketamine appear to be selectively involved in spatial memory mechanisms but may not be necessary for non-spatial memory consolidation. Expand
Differential effects of clozapine and haloperidol on ketamine-induced brain metabolic activation
TLDR
A striking neurobiological difference is demonstrated between the actions of prototypical typical and atypical antipsychotic drugs on ketamine- induced increases in [14C]-2-deoxyglucose (2-DG) uptake in the rat brain. Expand
Effects of GABAergic drugs on physostigmine-induced improvement in memory acquisition of passive avoidance learning in mice.
TLDR
It is concluded that both GABAA and GABAB activation inhibit improvement of acquisition induced by physostigmine. Expand
The effect of sub-anesthetic and anesthetic ketamine on water maze memory acquisition, consolidation and retrieval.
TLDR
It seems that NMDA receptor activity is not just necessary during water maze memory acquisition but also their post-learning reactivation is required to maintain memory consolidation and retrieval. Expand
Ketamine-Induced NMDA Receptor Hypofunction as a Model of Memory Impairment and Psychosis
TLDR
This double-blind, placebo-controlled, randomized, within-subjects comparison of three fixed subanesthetic, steady-state doses of intravenous ketamine in healthy males demonstrated dose-dependent increases in Brief Psychiatric Rating Scale positive and negative symptoms. Expand
Strain-dependent effects of post-training GABA receptor agonists and antagonists on memory storage in mice
TLDR
Post-training administration of the GABA-A and GABA-B receptor agonists muscimol and baclofen dose-dependently impaired retention of an inhibitory avoidance response in C57 mice, while improving memory consolidation in the DBA strain, while picrotoxin, bicuculline, and CGP 35348 dose-dependent improved retention in C 57 mice and impaired it in DBA mice. Expand
...
1
2
3
4
5
...