Recovery from glycerol-induced acute kidney injury is accelerated by suramin.

@article{Korrapati2012RecoveryFG,
  title={Recovery from glycerol-induced acute kidney injury is accelerated by suramin.},
  author={Midhun C. Korrapati and Brooke E. Shaner and Rick G Schnellmann},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2012},
  volume={341 1},
  pages={
          126-36
        }
}
Acute kidney injury (AKI) is a common and potentially life-threatening complication after ischemia/reperfusion and exposure to nephrotoxic agents. In this study, we examined the efficacy and mechanism(s) of suramin in promoting recovery from glycerol-induced AKI, a model of rhabdomyolysis-induced AKI. After intramuscular glycerol injection (10 ml of 50% glycerol per kilogram) into male Sprague-Dawley rats, serum creatinine maximally increased at 24 to 72 h and then decreased at 120 h… CONTINUE READING

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