Recovery from checkpoint-mediated arrest after repair of a double-strand break requires Srs2 helicase.

@article{Vaze2002RecoveryFC,
  title={Recovery from checkpoint-mediated arrest after repair of a double-strand break requires Srs2 helicase.},
  author={Moreshwar B. Vaze and Achille Pellicioli and Sang Eun Lee and Grzegorz Ira and Giordano Liberi and Ayelet Arbel-Eden and Marco Foiani and James E Haber},
  journal={Molecular cell},
  year={2002},
  volume={10 2},
  pages={373-85}
}
In Saccharomyces strains in which homologous recombination is delayed sufficiently to activate the DNA damage checkpoint, Rad53p checkpoint kinase activity appears 1 hr after DSB induction and disappears soon after completion of repair. Cells lacking Srs2p helicase fail to recover even though they apparently complete DNA repair; Rad53p kinase remains activated. srs2Delta cells also fail to adapt when DSB repair is prevented. The recovery defect of srs2Delta is suppressed in mec1Delta strains… CONTINUE READING
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