Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway.

@article{Desany1998RecoveryFD,
  title={Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway.},
  author={B A Desany and Annette A. Alcasabas and Jeffrey B. Bachant and Stephen J Elledge},
  journal={Genes & development},
  year={1998},
  volume={12 18},
  pages={
          2956-70
        }
}
RAD53 and MEC1 are essential genes required for the transcriptional and cell cycle responses to DNA damage and DNA replication blocks. We have examined the essential function of these genes and found that their lethality but not their checkpoint defects can be suppressed by increased expression of genes encoding ribonucleotide reductase. Analysis of viable null alleles revealed that Mec1 plays a greater role in response to inhibition of DNA synthesis than Rad53. The loss of survival in mec1 and… CONTINUE READING

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