Recovery by splenectomy in patients with relapsed thrombotic thrombocytopenic purpura and treatment failure to plasma exchange.

@article{Hoeffkes1995RecoveryBS,
  title={Recovery by splenectomy in patients with relapsed thrombotic thrombocytopenic purpura and treatment failure to plasma exchange.},
  author={Heinz Gert Hoeffkes and Franz Weber and Michael Uppenkamp and Peter J. Meusers and Christian Teschendorf and Th Philipp and G{\"u}nter Brittinger},
  journal={Seminars in thrombosis and hemostasis},
  year={1995},
  volume={21 2},
  pages={161-5}
}
Thrombotic thrombocytopenic purpura is a serious, potentially fatal disease, and conventional plasma exchange appears to be the best initial therapy. Following this approach, survival in 90% of patients is available. In patients with relapse and treatment failure to plasma exchange, splenectomy is recommended. The rationale for splenectomy and the relevant pathomechanisms involved are obscure. In the present paper two patients with TTP are reported who first responded to conventional treatment… CONTINUE READING