Recovering lost magnetization: polarization enhancement in biomolecular NMR.

  title={Recovering lost magnetization: polarization enhancement in biomolecular NMR.},
  author={Adrien Favier and Bernhard Brutscher},
  journal={Journal of biomolecular NMR},
  volume={49 1},
Experimental sensitivity remains a major drawback for the application of NMR spectroscopy to fragile and low concentrated biomolecular samples. Here we describe an efficient polarization enhancement mechanism in longitudinal-relaxation enhanced fast-pulsing triple-resonance experiments. By recovering undetectable (1)H polarization originating from longitudinal relaxation during the pulse sequence, the steady-state (15)N polarization becomes enhanced by up to a factor of ~5 with respect to… CONTINUE READING
Highly Cited
This paper has 38 citations. REVIEW CITATIONS

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 24 extracted citations

Evaluation of 15N-detected H-N correlation experiments on increasingly large RNAs.

Journal of biomolecular NMR • 2017
View 1 Excerpt
Method Support
Highly Influenced