Reconstruction of the metabolic network of Pseudomonas aeruginosa to interrogate virulence factor synthesis

@inproceedings{Bartell2017ReconstructionOT,
  title={Reconstruction of the metabolic network of Pseudomonas aeruginosa to interrogate virulence factor synthesis},
  author={Jennifer A Bartell and Anna S. Blazier and Phillip Yen and Juliane Charlotte Th\ogersen and Lars Jelsbak and Joanna B Goldberg and Jason A. Papin},
  booktitle={Nature communications},
  year={2017}
}
Virulence-linked pathways in opportunistic pathogens are putative therapeutic targets that may be associated with less potential for resistance than targets in growth-essential pathways. However, efficacy of virulence-linked targets may be affected by the contribution of virulence-related genes to metabolism. We evaluate the complex interrelationships between growth and virulence-linked pathways using a genome-scale metabolic network reconstruction of Pseudomonas aeruginosa strain PA14 and an… CONTINUE READING
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