Reconstruction of the Proto-Mitochondrial Metabolism

  title={Reconstruction of the Proto-Mitochondrial Metabolism},
  author={Toni Gabald{\'o}n and Martijn A. Huynen},
  pages={609 - 609}
Two new hypotheses explain the initial relationship between the alpha-proteobacterial ancestor (1, 2) of the mitochondrion (the proto-mitochondrion) and its host, one in which the proto-mitochondrion would have been an oxygen scavenger (3) and the other in which it would have been a hydrogenproducing, facultatively anaerobic species (4). Previous studies on the proto-mitochondrion’s metabolism have been based on 50 yeast mitochondrial proteins of alpha-proteobacterial origin (5). To also detect… Expand
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It is observed that mitochondria neither change their subcellular compartments in the course of evolution, even when their genes do, which is consistent with the complexity hypothesis, which argues that proteins that are a part of large, multi‐subunit complexes are unlikely to undergo horizontal gene transfer. Expand
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The pre-endosymbiont hypothesis: a new perspective on the origin and evolution of mitochondria.
  • M. W. Gray
  • Biology, Medicine
  • Cold Spring Harbor perspectives in biology
  • 2014
This model effectively represents a synthesis of previous, contending mitochondrial origin hypotheses, with the bulk of the mitochondrial proteome (much of the NPC) having an endogenous origin and the minority component (the APC) having a xenogenous origin. Expand
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Previously overlooked information on methanotrophic bacteria, in particular their intracytoplasmic membranes resembling mitochondrial cristae and their capacity of establishing endosymbiotic relationships with invertebrate animals and archaic plants are discussed. Expand
Relative timing of mitochondrial endosymbiosis and the “pre‐mitochondrial symbioses” hypothesis
It is argued that simple eukaryogenesis models that assume a binary symbiosis between an archaeon host and an alpha‐proteobacterial proto‐mitochondrion cannot explain the complex chimeric nature that is inferred for the eUKaryotic ancestor. Expand
From Endosymbiont to Host-Controlled Organelle: The Hijacking of Mitochondrial Protein Synthesis and Metabolism
The results indicate that the eukaryotic host has hijacked the proto-mitochondrion, taking control of its protein synthesis and metabolism. Expand
The Origin and Diversification of Mitochondria
Since the establishment of the organelle, proteins have been gained, lost, transferred and retargeted as mitochondria have specialized into the spectrum of functional types seen across the eukaryotic tree of life. Expand
Phylogenomic Evidence for a Myxococcal Contribution to the Mitochondrial Fatty Acid Beta-Oxidation
The data suggest that myxococcal species with the ability to oxidize fatty acids transferred several genes to eubacteria that eventually gave rise to the mitochondrial ancestor, which supported a prokaryotic origin, different from α-proteobacteria, for several mitochondrial genes. Expand


Origin and Evolution of the Mitochondrial Proteome
There are no phylogenetic indications either in the mitochondrial proteome or in the nuclear genomes that the initial or subsequent function of the ancestor to the mitochondria was anaerobic, and there are indications that relatively advanced eukaryotes adapted to anaerobiosis by dismantling their mitochondria and refitting them as hydrogenosomes. Expand
The Dual Origin of the Yeast Mitochondrial Proteome
The proposed scheme for the origin of mitochondria based on phylogenetic reconstructions with more than 400 yeast nuclear genes that encode mitochondrial proteins suggests that the majority of genes encoding yeast mitochondrial proteins are descendants of two different genomic lineages that have evolved in different modes. Expand
Mitochondrial evolution : Mitochondria
Gene sequence data strongly support a monophyletic origin of the mitochondrion from a eubacterial ancestor shared with a subgroup of the α-Proteobacteria and raise the possibility that this organelle originated at essentially the same time as the nuclear component of the eukaryotic cell rather than in a separate, subsequent event. Expand
An Overview of Endosymbiotic Models for the Origins of Eukaryotes, Their ATP-Producing Organelles (Mitochondria and Hydrogenosomes), and Their Heterotrophic Lifestyle
Traditional models are contrasted to an alternative endosymbiotic model (the hydrogen hypothesis), which addresses theorigin of heterotrophy and the origin of compartmentalized energy metabolism in eukaryotes. Expand
The genome sequence of Rickettsia prowazekii and the origin of mitochondria
The complete genome sequence of the obligate intracellular parasite Rickettsia prowazekii, the causative agent of epidemic typhus, is described, which contains 834 protein-coding genes and is more closely related to mitochondria than is any other microbe studied so far. Expand
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This work investigates the individual evolutionary histories of all of the enzymes of the tricarboxylic acid cycle and the glyoxylate cycle using protein maximum likelihood phylogenies, focusing on the evolutionary origin of the nuclear-encoded proteins in higher plants. Expand