Reconstruction of the Mouse Otocyst and Early Neuroblast Lineage at Single-Cell Resolution

  title={Reconstruction of the Mouse Otocyst and Early Neuroblast Lineage at Single-Cell Resolution},
  author={Robert Durruthy-Durruthy and Assaf Gottlieb and Byron H. Hartman and Joerg Waldhaus and Roman D. Laske and Russ Altman and Stefan Heller},
The otocyst harbors progenitors for most cell types of the mature inner ear. Developmental lineage analyses and gene expression studies suggest that distinct progenitor populations are compartmentalized to discrete axial domains in the early otocyst. Here, we conducted highly parallel quantitative RT-PCR measurements on 382 individual cells from the developing otocyst and neuroblast lineages to assay 96 genes representing established otic markers, signaling-pathway-associated transcripts, and… CONTINUE READING
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neurogenin 1 is essential for the determination of

  • Q. Ma, Z. Chen, I. del Barco Barrantes, J. L. de la Pompa, D. J. Anderson
  • 1998
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