Reconstruction of phyletic trees by global alignment of multiple metabolic networks

  title={Reconstruction of phyletic trees by global alignment of multiple metabolic networks},
  author={Cheng-Yu Ma and Shu-Hsi Lin and Chi-Ching Lee and Chuan Yi Tang and Bonnie Berger and Chung-Shou Liao},
  booktitle={BMC Bioinformatics},
In the last decade, a considerable amount of research has been devoted to investigating the phylogenetic properties of organisms from a systems-level perspective. Most studies have focused on the classification of organisms based on structural comparison and local alignment of metabolic pathways. In contrast, global alignment of multiple metabolic networks complements sequence-based phylogenetic analyses and provides more comprehensive information. We explored the phylogenetic relationships… CONTINUE READING


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