Reconstruction of hippocampal granule cell electrophysiology by computer simulation.

  title={Reconstruction of hippocampal granule cell electrophysiology by computer simulation.},
  author={G. L. Yuen and Dominique M. Durand},
  volume={41 2-3},
A model of the hippocampal granule cells was created that closely approximated most of the measured intracellular responses from a neuron under a variety of stimulus conditions. This model suggests that: (1) A simple, four-conductance model can account for most of the intracellular behavior of these neurons. (2) The repolarization mechanism in granule cells may be different from that in squid axons. A weak potassium conductance may be present in hippocampal granule neurons, which simultaneously… CONTINUE READING
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