Reconstruction of hepatic organoid by rat small hepatocytes and hepatic nonparenchymal cells

@article{Mitaka1999ReconstructionOH,
  title={Reconstruction of hepatic organoid by rat small hepatocytes and hepatic nonparenchymal cells},
  author={T. Mitaka and F. Sato and T. Mizuguchi and T. Yokono and Y. Mochizuki},
  journal={Hepatology},
  year={1999},
  volume={29}
}
Hepatic cells isolated from an adult rat liver, consisting of small hepatocytes (SHs), mature hepatocytes (MHs), liver epithelial cells (LECs), Kupffer cells, sinusoidal endothelial cells, and stellate cells, were cultured in a medium supplemented with 10% fetal bovine serum, 10 mmol/L nicotinamide, 1 mmol/L ascorbic acid 2‐phosphate, 10 ng/mL epidermal growth factor, and 1% dimethyl sulfoxide. The SHs rapidly proliferated and formed a colony. About 10% of cytokeratin 8 (CK8)‐positive cells… Expand
Transplantation of embryonic small hepatocytes induces regeneration of injured liver in adult rat.
Enrichment of hepatic progenitor cells from adult mouse liver
Differentiation capacity of hepatic stem/progenitor cells isolated from D‐galactosamine‐treated rat livers
Bile canalicular formation in hepatic organoid reconstructed by rat small hepatocytes and nonparenchymal cells
Re-evaluation of liver stem/progenitor cells
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