Reconstruction of functionally normal and malignant human breast tissues in mice.

  title={Reconstruction of functionally normal and malignant human breast tissues in mice.},
  author={Charlotte Kuperwasser and Tony E Chavarria and M. X. Wu and Greg Magrane and Joe W. Gray and Loucinda Carey and Andrea Richardson and Robert A Weinberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 14},
The study of normal breast epithelial morphogenesis and carcinogenesis in vivo has largely used rodent models. Efforts at studying mammary morphogenesis and cancer with xenotransplanted human epithelial cells have failed to recapitulate the full extent of development seen in the human breast. We have developed an orthotopic xenograft model in which both the stromal and epithelial components of the reconstructed mammary gland are of human origin. Genetic modification of human stromal cells… CONTINUE READING
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