Reconstruction of complex single-cell trajectories using CellRouter

@article{LummertzdaRocha2018ReconstructionOC,
  title={Reconstruction of complex single-cell trajectories using CellRouter},
  author={Edroaldo Lummertz da Rocha and Robert Grant Rowe and Vanessa Lundin and Mohan Malleshaiah and Deepak Kumar Jha and Carlos Renato Rambo and Hu Li and Trista E. North and James J. Collins and George Q. Daley},
  journal={Nature Communications},
  year={2018},
  volume={9}
}
A better understanding of the cell-fate transitions that occur in complex cellular ecosystems in normal development and disease could inform cell engineering efforts and lead to improved therapies. However, a major challenge is to simultaneously identify new cell states, and their transitions, to elucidate the gene expression dynamics governing cell-type diversification. Here, we present CellRouter, a multifaceted single-cell analysis platform that identifies complex cell-state transition… 

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