Reconstruction of complex single-cell trajectories using CellRouter

@article{Rocha2018ReconstructionOC,
  title={Reconstruction of complex single-cell trajectories using CellRouter},
  author={Edroaldo Lummertz da Rocha and R. G. Rowe and Vanessa Lundin and Mohan K. Malleshaiah and D. Jha and C. Rambo and Hu Li and T. North and J. J. Collins and G. Daley},
  journal={Nature Communications},
  year={2018},
  volume={9}
}
A better understanding of the cell-fate transitions that occur in complex cellular ecosystems in normal development and disease could inform cell engineering efforts and lead to improved therapies. However, a major challenge is to simultaneously identify new cell states, and their transitions, to elucidate the gene expression dynamics governing cell-type diversification. Here, we present CellRouter, a multifaceted single-cell analysis platform that identifies complex cell-state transition… Expand
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