Reconstruction of cellular signalling networks and analysis of their properties

@article{Papin2005ReconstructionOC,
  title={Reconstruction of cellular signalling networks and analysis of their properties},
  author={Jason A. Papin and Tony Hunter and Bernhard O. Palsson and Shankar Subramaniam},
  journal={Nature Reviews Molecular Cell Biology},
  year={2005},
  volume={6},
  pages={99-111}
}
The study of cellular signalling over the past 20 years and the advent of high-throughput technologies are enabling the reconstruction of large-scale signalling networks. After careful reconstruction of signalling networks, their properties must be described within an integrative framework that accounts for the complexity of the cellular signalling network and that is amenable to quantitative modelling. 
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