Reconstruction of a replication-competent ancestral murine endogenous retrovirus-L

@inproceedings{BlancoMelo2018ReconstructionOA,
  title={Reconstruction of a replication-competent ancestral murine endogenous retrovirus-L},
  author={Daniel Blanco-Melo and Robert James Gifford and Paul D Bieniasz},
  booktitle={Retrovirology},
  year={2018}
}
About 10% of the mouse genome is composed of endogenous retroviruses (ERVs) that represent a molecular fossil record of past retroviral infections. One such retrovirus, murine ERV-L (MuERV-L) is an env-deficient ERV that has undergone episodic proliferation, with the most recent amplification occurring ~ 2 million years ago. MuERV-L related sequences have been co-opted by mice for antiretroviral defense, and possibly as promoters for some genes that regulate totipotency in early mouse embryos… CONTINUE READING