Reconstruction and analysis of a signal transduction network using HeLa cell protein–protein interaction data

@inproceedings{Wu2014ReconstructionAA,
  title={Reconstruction and analysis of a signal transduction network using HeLa cell protein–protein interaction data},
  author={Pei-Jung Wu and Wu-Hsiung Wu and Tzu-Chi Chen and Kuan-Ting Lin and Jin-mei Lai and Chi-Ying F. Huang and Feng-Sheng Wang},
  year={2014}
}
Cancer is a complex disease that is strongly associated with defects in signal transduction pathways. A systematic understanding of signal transduction networks in cancer cells will make it possible to develop alternative therapeutic strategies. However, this understanding relies, at least in part, on the detection of endogenous protein–protein interactions (PPIs) that participate in these networks. The aim of this study is to find intervention strategies under the assumptions of inhibiting… CONTINUE READING