Reconstructing the human hematopoietic niche in immunodeficient mice: opportunities for studying primary multiple myeloma.

@article{Groen2012ReconstructingTH,
  title={Reconstructing the human hematopoietic niche in immunodeficient mice: opportunities for studying primary multiple myeloma.},
  author={Richard W. J. Groen and Willy A. Noort and Reinier A. P. Raymakers and H A B Prins and Linda Aalders and Frans M. A. Hofhuis and Petra Moerer and Jeroen van Velzen and Andries C. Bloem and Berris van Kessel and Henk Rozemuller and Ellen van Binsbergen and Arjan Buijs and Huipin Yuan and Joost D. de Bruijn and Michel de Weers and Paul W H I Parren and Jan Jacob Schuringa and Henk M. Lokhorst and Tuna Mutis and Anton C. M. Martens},
  journal={Blood},
  year={2012},
  volume={120 3},
  pages={e9-e16}
}
Interactions within the hematopoietic niche in the BM microenvironment are essential for maintenance of the stem cell pool. In addition, this niche is thought to serve as a sanctuary site for malignant progenitors during chemotherapy. Therapy resistance induced by interactions with the BM microenvironment is a major drawback in the treatment of hematologic malignancies and bone-metastasizing solid tumors. To date, studying these interactions was hampered by the lack of adequate in vivo models… CONTINUE READING
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