Reconstructing the evolutionary history of the artiodactyl ribonuclease superfamily

@article{Jermann1995ReconstructingTE,
  title={Reconstructing the evolutionary history of the artiodactyl ribonuclease superfamily},
  author={Thomas M. Jermann and Jochen G. Opitz and Joseph Stackhouse and Steven A. Benner},
  journal={Nature},
  year={1995},
  volume={374},
  pages={57-59}
}
THE sequences of proteins from ancient organisms can be reconstructed from the sequences of their descendants by a procedure that assumes that the descendant proteins arose from the extinct ancestor by the smallest number of independent evolutionary events (‘parsimony’)1,2. The reconstructed sequences can then be prepared in the laboratory and studied3,4. Thirteen ancient ribonucleases (RNases) have been reconstructed as intermediates in the evolution of the RNase protein family in artiodactyls… 

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