Reconstructing the differentiation niche of embryonic stem cells using biomaterials.

  title={Reconstructing the differentiation niche of embryonic stem cells using biomaterials.},
  author={Laura E. Dickinson and S. Lakshmi Kusuma and Sharon Gerecht},
  journal={Macromolecular bioscience},
  volume={11 1},
The biochemical cues and topographical architecture of the extracellular environment extensively influence ES cell fate. The microenvironment surrounding the developing embryo presents these instructive cues in a complex and interactive manner in order to guide cell fate decisions. Current stem cell research aims to reconstruct this multifaceted embryonic niche to recapitulate development in vitro. This review focuses on 2D and 3D differentiation niches created from natural and synthetic… CONTINUE READING

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