Reconstructing the differentiation niche of embryonic stem cells using biomaterials.

@article{Dickinson2011ReconstructingTD,
  title={Reconstructing the differentiation niche of embryonic stem cells using biomaterials.},
  author={L. Dickinson and S. Kusuma and S. Gerecht},
  journal={Macromolecular bioscience},
  year={2011},
  volume={11 1},
  pages={
          36-49
        }
}
  • L. Dickinson, S. Kusuma, S. Gerecht
  • Published 2011
  • Medicine, Chemistry
  • Macromolecular bioscience
  • The biochemical cues and topographical architecture of the extracellular environment extensively influence ES cell fate. The microenvironment surrounding the developing embryo presents these instructive cues in a complex and interactive manner in order to guide cell fate decisions. Current stem cell research aims to reconstruct this multifaceted embryonic niche to recapitulate development in vitro. This review focuses on 2D and 3D differentiation niches created from natural and synthetic… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 175 REFERENCES
    Embryonic stem cell lines derived from human blastocysts.
    • 13,439
    • Open Access
    Geometric control of cell life and death.
    • 4,089
    • Open Access
    Hyaluronan: from extracellular glue to pericellular cue
    • 1,567
    Hydrogels in regenerative medicine.
    • 1,490
    • Open Access
    Exploring and Engineering the Cell Surface Interface
    • 1,817