Reconstructing the coding and non-coding RNA regulatory networks of miRNAs and mRNAs in breast cancer.

@article{Yang2014ReconstructingTC,
  title={Reconstructing the coding and non-coding RNA regulatory networks of miRNAs and mRNAs in breast cancer.},
  author={Sheng Yang and Hui Zhang and Li Guo and Yang Zhao and Feng Chen},
  journal={Gene},
  year={2014},
  volume={548 1},
  pages={6-13}
}
microRNAs (miRNAs) are a class of small non-coding RNAs that deregulate and/or decrease the expression of target messenger RNAs (mRNAs), which specifically contribute to complex diseases. In our study, we reanalyzed an integrated data to promote classification performance by rebuilding miRNA-mRNA modules, in which a group of deregulated miRNAs cooperatively regulated a group of significant mRNAs. In five-fold cross validation, the multiple processes flow considered the biological and… CONTINUE READING