Reconstructing the History of Human Limb Development: Lessons from Birth Defects

@article{Bamshad1999ReconstructingTH,
  title={Reconstructing the History of Human Limb Development: Lessons from Birth Defects},
  author={Michael Bamshad and W. Scott Watkins and Mary E. Dixon and Trung Le and Amy D. Roeder and Bridget E Kramer and John C Carey and Lynn B. Jorde},
  journal={Pediatric Research},
  year={1999},
  volume={45},
  pages={291-299}
}
A major goal of biology has been to understand the developmental mechanisms behind evolutionary trends. This has led to a growing interest in studying the molecular basis of the evolution of developmental programs such as those mediating the diversification of tetrapod limbs. Over the last 10 y, it has become clear that the genes and general developmental programs used to build a limb are strongly conserved among widely disparate species. This finding suggests that altered regulation of the… CONTINUE READING