Reconstructing large regions of an ancestral mammalian genome in silico.

@article{Blanchette2004ReconstructingLR,
  title={Reconstructing large regions of an ancestral mammalian genome in silico.},
  author={Mathieu Blanchette and Eric D. Green and Webb Miller and David Haussler},
  journal={Genome research},
  year={2004},
  volume={14 12},
  pages={2412-23}
}
It is believed that most modern mammalian lineages arose from a series of rapid speciation events near the Cretaceous-Tertiary boundary. It is shown that such a phylogeny makes the common ancestral genome sequence an ideal target for reconstruction. Simulations suggest that with methods currently available, we can expect to get 98% of the bases correct in reconstructing megabase-scale euchromatic regions of an eutherian ancestral genome from the genomes of approximately 20 optimally chosen… CONTINUE READING

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Identification and characterization of multi-species conserved sequences

  • E. H. Margulies, M. Blanchette, NISC Comparative Sequencing Program, D. Haussler, E. Green
  • Genome Res. 13: 2507–2518.
  • 2003
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