Reconstructing cortical connections in a dish.


During development of the cortex, efferent projection neurons located in distinct cortical layers send their axons to different targets, and afferent fibers establish connections with cortical target cells of a particular layer. Recent studies have shown that layer- and cell-specific afferent and efferent cortical connections established in culture are similar to those observed in vivo. The results of these experiments provide evidence for the existence of diffusible and membrane-bound guidance factors for specific sets of axons. Furthermore, they suggest the use of different molecules to navigate axons towards their target, regulate target innervation and mediate target cell recognition.


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@article{Bolz1993ReconstructingCC, title={Reconstructing cortical connections in a dish.}, author={Jeffrey Bolz and Magdalena G{\"{o}tz and Mark H{\"{u}bener and Nurit Novak}, journal={Trends in neurosciences}, year={1993}, volume={16 8}, pages={310-6} }