Reconstructing complex regions of genomes using long-read sequencing technology.


Obtaining high-quality sequence continuity of complex regions of recent segmental duplication remains one of the major challenges of finishing genome assemblies. In the human and mouse genomes, this was achieved by targeting large-insert clones using costly and laborious capillary-based sequencing approaches. Sanger shotgun sequencing of clone inserts… (More)
DOI: 10.1101/gr.168450.113


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