Reconstructing a missing link in the evolution of a recently diverged phosphotriesterase by active-site loop remodeling.

@article{AfriatJurnou2012ReconstructingAM,
  title={Reconstructing a missing link in the evolution of a recently diverged phosphotriesterase by active-site loop remodeling.},
  author={Livnat Afriat-Jurnou and Colin J Jackson and Dan S. Tawfik},
  journal={Biochemistry},
  year={2012},
  volume={51 31},
  pages={6047-55}
}
Only decades after the introduction of organophosphate pesticides, bacterial phosphotriesterases (PTEs) have evolved to catalyze their degradation with remarkable efficiency. Their closest known relatives, lactonases, with promiscuous phosphotriasterase activity, dubbed PTE-like lactonases (PLLs), share only 30% sequence identity and also differ in the configuration of their active-site loops. PTE was therefore presumed to have evolved from a yet unknown PLL whose primary activity was the… CONTINUE READING
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