Reconstructing Denisovan Anatomy Using DNA Methylation Maps

@article{Gokhman2019ReconstructingDA,
  title={Reconstructing Denisovan Anatomy Using DNA Methylation Maps},
  author={David Gokhman and Nadav Mishol and Marc de Manuel and D. Juan and L. Carmel},
  journal={Cell},
  year={2019},
  volume={179},
  pages={180-192.e10}
}
  • David Gokhman, Nadav Mishol, +2 authors L. Carmel
  • Published 2019
  • Biology, Medicine
  • Cell
  • Denisovans are an extinct group of humans whose morphology remains unknown. Here, we present a method for reconstructing skeletal morphology using DNA methylation patterns. Our method is based on linking unidirectional methylation changes to loss-of-function phenotypes. We tested performance by reconstructing Neanderthal and chimpanzee skeletal morphologies and obtained >85% precision in identifying divergent traits. We then applied this method to the Denisovan and offer a putative… CONTINUE READING
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