Reconstructing Denisovan Anatomy Using DNA Methylation Maps

@article{Gokhman2019ReconstructingDA,
  title={Reconstructing Denisovan Anatomy Using DNA Methylation Maps},
  author={David Gokhman and Nadav Mishol and Marc de Manuel and D. Juan and L. Carmel},
  journal={Cell},
  year={2019},
  volume={179},
  pages={180-192.e10}
}
  • David Gokhman, Nadav Mishol, +2 authors L. Carmel
  • Published 2019
  • Biology, Medicine
  • Cell
  • Denisovans are an extinct group of humans whose morphology remains unknown. Here, we present a method for reconstructing skeletal morphology using DNA methylation patterns. Our method is based on linking unidirectional methylation changes to loss-of-function phenotypes. We tested performance by reconstructing Neanderthal and chimpanzee skeletal morphologies and obtained >85% precision in identifying divergent traits. We then applied this method to the Denisovan and offer a putative… CONTINUE READING
    14 Citations

    Topics from this paper

    Differential DNA methylation of vocal and facial anatomy genes in modern humans
    • 8
    • PDF
    Assessing DNA Sequence Alignment Methods for Characterizing Ancient Genomes and Methylomes
    • 1
    • PDF
    Harnessing epigenetics to study human evolution.
    • PDF
    Archaic hominin genomics provides a window into gene expression evolution.
    • 1
    Ghost Introgression: Spooky Gene Flow in the Distant Past
    • Jente Ottenburghs
    • Biology, Medicine
    • BioEssays : news and reviews in molecular, cellular and developmental biology
    • 2020
    • 8
    First portrait of mysterious Denisovans drawn from DNA
    • PDF
    [Forensic phenotyping: How far along?]
    • B. Jordan
    • Geography, Medicine
    • Medecine sciences : M/S
    • 2020

    References

    SHOWING 1-10 OF 81 REFERENCES
    A High-Coverage Genome Sequence from an Archaic Denisovan Individual
    • 1,330
    • PDF
    Inferring Past Environments from Ancient Epigenomes
    • 22
    • PDF
    A fourth Denisovan individual
    • 40
    • PDF
    Genetic history of an archaic hominin group from Denisova Cave in Siberia
    • 1,280
    • PDF
    Genome-wide nucleosome map and cytosine methylation levels of an ancient human genome.
    • 118
    • PDF
    Archaic Adaptive Introgression in TBX15/WARS2
    • 68
    • PDF
    Nuclear and mitochondrial DNA sequences from two Denisovan individuals
    • 113
    • PDF