Reconstitution of the T cell receptor alpha beta repertoire in recipients of allogeneic BMT.

@article{Rencher1992ReconstitutionOT,
  title={Reconstitution of the T cell receptor alpha beta repertoire in recipients of allogeneic BMT.},
  author={Samantha D. Rencher and I Hanif and Helen E Heslop and Virginia Turner and Malcolm K. Brenner and Julia L. Hurwitz},
  journal={Bone marrow transplantation},
  year={1992},
  volume={10 6},
  pages={521-7}
}
This report describes the qualitative analysis of T cell receptor (TCR) repertoire regeneration in recipients of BMT. RNA samples from patient and control peripheral blood lymphocytes were prepared and tested for the presence of multiple V alpha and V beta transcripts by the polymerase chain reaction. TCR V gene expression was highly diverse within the first 6 months post-transplantation in recipients receiving either T cell-depleted or T cell-replete marrow, and in HLA mismatched as well as… CONTINUE READING