Reconstitution of the CstF complex unveils a regulatory role for CstF-50 in recognition of 3′-end processing signals

@inproceedings{Yang2018ReconstitutionOT,
  title={Reconstitution of the CstF complex unveils a regulatory role for CstF-50 in recognition of 3′-end processing signals},
  author={Wen Yang and Peter L. Hsu and Fan Yang and Jae-Eun Song and Gabriele Varani},
  booktitle={Nucleic acids research},
  year={2018}
}
Cleavage stimulation factor (CstF) is a highly conserved protein complex composed of three subunits that recognizes G/U-rich sequences downstream of the polyadenylation signal of eukaryotic mRNAs. While CstF has been identified over 25 years ago, the architecture and contribution of each subunit to RNA recognition have not been fully understood. In this study, we provide a structural basis for the recruitment of CstF-50 to CstF via interaction with CstF-77 and establish that the hexameric… CONTINUE READING
2
Twitter Mentions

Citations

Publications citing this paper.

References

Publications referenced by this paper.
SHOWING 1-10 OF 45 REFERENCES

REFMAC5 for the refinement of macromolecular crystal structures

  • Acta crystallographica. Section D, Biological crystallography
  • 2011
VIEW 1 EXCERPT