Reconstitution of papillomavirus E2-mediated plasmid maintenance in Saccharomyces cerevisiae by the Brd4 bromodomain protein.

@article{Brannon2005ReconstitutionOP,
  title={Reconstitution of papillomavirus E2-mediated plasmid maintenance in Saccharomyces cerevisiae by the Brd4 bromodomain protein.},
  author={Angela Rose Brannon and Julia A Maresca and Jef D. Boeke and Munira A. Basrai and Alison A. McBride},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 8},
  pages={2998-3003}
}
The papillomavirus E2 protein functions in viral transcriptional regulation, DNA replication, and episomal genome maintenance. Viral genomes are maintained in dividing cells by attachment to mitotic chromosomes by means of the E2 protein. To investigate the chromosomal tethering function of E2, plasmid stability assays were developed in Saccharomyces cerevisiae to determine whether the E2 protein could maintain plasmids containing the yeast autonomous replication sequence replication element… CONTINUE READING