Reconstitution of membrane proteolysis by FtsH.

  title={Reconstitution of membrane proteolysis by FtsH.},
  author={Yoshinori Akiyama and Koreaki Ito},
  journal={The Journal of biological chemistry},
  volume={278 20},
Escherichia coli FtsH is a membrane-bound and ATP-dependent protease responsible for degradation of several membrane proteins. The FtsH action is processive and presumably involves dislocation of the substrate from the membrane to the cytosol. Although elucidation of its molecular mechanism requires an in vitro reaction system, in vitro activities of this enzyme against membrane protein substrates have only been assayed using detergent-solubilized components. Here we report on the construction… CONTINUE READING

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