Reconstitution of membrane proteins into lipid-rich bilayered mixed micelles for NMR studies.

@article{Sanders1995ReconstitutionOM,
  title={Reconstitution of membrane proteins into lipid-rich bilayered mixed micelles for NMR studies.},
  author={Charles R Sanders and G C Landis},
  journal={Biochemistry},
  year={1995},
  volume={34 12},
  pages={4030-40}
}
This paper describes a study undertaken to assess the possibility and practical consequences of reconstituting integral and peripheral membrane proteins into bilayered discoidal mixed micelles ("bicelles") composed of dimyristoylphosphatidylcholine and smaller amounts of either CHAPSO or short-chain phosphatidylcholine. The amphiphilic assemblies in these mixtures are uniquely suited for use in NMR structural studies because they can be magnetically oriented with experimentally-tunable system… CONTINUE READING

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