Reconstitution of interactions between the Src tyrosine kinases and Ras GTPase-activating protein using a baculovirus expression system.

@article{Park1992ReconstitutionOI,
  title={Reconstitution of interactions between the Src tyrosine kinases and Ras GTPase-activating protein using a baculovirus expression system.},
  author={Sung Hyun Park and Mark S. Marshall and Jackson B. Gibbs and Richard Jove},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 16},
  pages={11612-8}
}
Ras GTPase-activating protein (GAP) has been implicated in mitogenic signal transduction downstream of oncogenic and receptor tyrosine kinases. Previous studies have suggested that GAP is phosphorylated by oncogenic viral Src (v-Src) and that GAP is associated with a complex containing normal cellular Src (c-Src) in vertebrate fibroblasts. To investigate… CONTINUE READING