Reconstitution of human hematopoietic function with autologous cryopreserved circulating stem cells.

@article{Kessinger1986ReconstitutionOH,
  title={Reconstitution of human hematopoietic function with autologous cryopreserved circulating stem cells.},
  author={Anne M Kessinger and James Olen Armitage and James D Landmark and Dennis D. Weisenburger},
  journal={Experimental hematology},
  year={1986},
  volume={14 3},
  pages={192-6}
}
Complete hematopoietic reconstitution using nonleukemic peripheral blood mononuclear cells has been achieved in animal models but not in humans. We treated two patients who had metastatic breast carcinoma involving the bone marrow and who had failed conventional therapy with high-dose chemotherapy and total body radiation. Cryopreserved autologous peripheral blood mononuclear cells (6.3-8.4 X 10(8)/kg patient weight) obtained by leukapheresis before high-dose therapy were returned to the… CONTINUE READING

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